For the direct and fast reversal of VKA therapy Cofact is needed. The dosage of Cofact depends on the INR before treatment, the targeted INR and bodyweight. The targeted INR depends on the severity of the clinical situation. This dosing guide determines the dosage of Cofact for two different situations. These situations acts as a guiding principle: in case of a minor (urgent) surgery of serious overdosing of anticoagulant you aim for a target INR of at least 2.1 (situation A), or you aim for a target INR of at least 1.5 in case of a major or life threatening bleeding/surgery (situation B). Depending on the weight of the patient and the actual INR (before treatment) the dosage of Cofact in ml will be given.
Because of the risk of thrombo-embolic complications, close monitoring should be exercised when administering human prothrombin complex to patients with a history of coronary heart disease, to patients with liver disease, to per- or post-operative patients, to neonates or to patients at risk of thrombo-embolic events or disseminated intravascular coagulation. In each of these situations, the potential benefit of treatment should be weighed against the risks of these complications.
Cofact Dosing App is a free software application from the Health & Nutrition subcategory, part of the Home & Hobby category.
The app is currently available in English and it was last updated on 2014-03-24. The program can be installed on Android.
Cofact Dosing App (version 1.1.0) has a file size of 1.15 MB and is available for download from our website.
Just click the green Download button above to start. Until now the program was downloaded 17 times.
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